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An Adverse Outcome Pathway for Potential Space Radiation Induced Neurological Diseases Astronauts have begun to spend increasingly longer periods in space, putting themselves in foreign environments in order to explore the unknown. Space radiation is one of the largest health risks faced by astronauts on their missions. The space radiation environment has the ability to cause high levels of irreversible damage. Multiple sources of charged particle radiation exist in the space environment that may increase risk of carcinogenesis, degeneration of bodily tissue (e.g. gastrointestinal, cardiovascular, or pulmonary), acute radiation syndromes, and acute and late central nervous system (CNS) disorders. In order to help inform an understanding of the risk of degenerative CNS disease due to radiation exposure, an initial step is presented here to develop an adverse outcome pathway from radiation exposure focused on Alzheimer’s disease.
Document ID
20200001144
Acquisition Source
Langley Research Center
Document Type
Technical Publication (TP)
Authors
Mi, Kaitlyn
(Brown Univ. Providence, RI, United States)
Norman, Ryan B.
(NASA Langley Research Center Hampton, VA, United States)
Date Acquired
February 25, 2020
Publication Date
February 1, 2020
Subject Category
Aerospace Medicine
Report/Patent Number
NASA/TP-2020-220443
NF1676L-35691
L-21110
Distribution Limits
Public
Copyright
Public Use Permitted.
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