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Cosmos-1989 immunology studiesEvidence from both human and rodent studies has indicated that alterations in immunological parameters occur after space flight. The number of flight experiments has been small, and the full breadth of immunological alterations occurring after space flight remains to be established. Among the major effects on immune responses after space flight that have been reported are: alterations in lymphocyte blastogenesis and natural killer cell activity, alterations in production of cytokines, changes in leukocyte sub-population distribution, and decreases in the ability in the ability of bone marrow cells to respond to colony stimulating factors. Changes have been reported in immunological parameters of both humans and rodents. The significance of these alterations in relation to resistance to infection remains to be established. The current study involved a determination of the effects of flight on Cosmos mission 2044 on leukocyte subset distribution and the sensitivity of bone marrow cells to colony stimulating factor-GM. A parallel study with antiorthostatic suspension was also carried out. The study involved repetition and expansion of studies carried out on Cosmos 1887.
Document ID
19920003171
Acquisition Source
Legacy CDMS
Document Type
Contractor Report (CR)
Authors
Sonnenfeld, Gerald
(Louisville Univ. KY, United States)
Date Acquired
September 6, 2013
Publication Date
October 1, 1991
Subject Category
Life Sciences (General)
Report/Patent Number
NASA-CR-188970
NAS 1.26:188970
Accession Number
92N12389
Funding Number(s)
CONTRACT_GRANT: NAG2-614
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
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